NS FL4 BIO Q4

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Vasiliy_B
Posts: 7
Joined: Thu Feb 21, 2019 7:36 pm

NS FL4 BIO Q4

Post by Vasiliy_B » Sat Mar 09, 2019 12:37 pm

The explanation says:
"Paragraph 2 tells us that pyrivinium is effective against cancers in glucose-starvation conditions. If colon cancers rely less on glycolysis (and thus would be less directly affected by glucose-starvation conditions) then we would expect pyrivinium to be less effective against colon cancers, and thus more effective against BP-CML."

Paragraph 2 says:
"Pyrivinium, a drug used to treat pinworm infections, has gained attention in recent years as the drug has shown a significant ability to compromise the survival of cancer cells under glucose-starvation conditions. Though its mechanisms of action are not fully understood, researchers have demonstrated that it disrupts intracellular signaling pathways in colon cancer by allosterically activating protein CK1⍺. However, this mechanism does not fully account for the demonstrated efficacy of pyrivinium against blast phase chronic myeloid leukemia (BP-CML) cells."

I understand that we can infer from the first sentence that certain cancers should depend less on glucose. But how should we distinguish that this would be true for colon cancer but not for leukemia? A clarification would be much appreciated.

Thank you,

Vasiliy
NS_Tutor_Will
Posts: 395
Joined: Fri May 25, 2018 9:15 am

Re: NS FL4 BIO Q4

Post by NS_Tutor_Will » Sun Mar 10, 2019 9:12 am

Thanks for the question!

I think the key here is that we're looking for something that would support the idea that the drug is more effective in one type of cancer than another. Like you said, we can determine that there will be metabolic differences from the passage. We also know from the passage that pyrivinium disrupts cancer cells that are in glucose-starved conditions ("compromise the survival of cancer cells under glucose-starvation conditions"). If a cancer cell didn't rely on glycolysis for energy production, then glucose-starvation conditions wouldn't really affect it. Since we're trying to support the idea that the drug is less effective against colon cancer (as compared to BP-CML), then we should propose that colon cancers don't rely on glycolysis, don't experience glucose-starvation conditions, and therefore aren't able to be treated with pyrivinium.

There are a lot of steps to it, but I hope this is helpful!
Vasiliy_B
Posts: 7
Joined: Thu Feb 21, 2019 7:36 pm

Re: NS FL4 BIO Q4

Post by Vasiliy_B » Thu Mar 14, 2019 5:23 pm

Thank you Will, this helped!
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