Lesson 13, Video 3/10

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Lesson 13, Video 3/10

Post by dtha9180 » Tue Aug 28, 2018 4:42 pm

Hi, in this video, Dr. Anthony said the activity of glucose 6 phosphatase is increased with the addition of glucose 6 phosphate. This will lead to more glucose. However, he also said this will addition of glucose will result in glycolysis unable to proceed. Please see attached for screenshot.

I wanted to ask why would glycolysis be unable to proceed with more glucose produced? This would increase substrate, which will, according to Le Chatlier's principle, result in an increased rate of hexokinase and glycolysis as a whole. Maybe I am getting something wrong. Please help, thank you!
Screenshot 2018-08-28 15.35.25.png
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Re: Lesson 13, Video 3/10

Post by NS_Tutor_Phil » Tue Sep 04, 2018 5:16 pm

Hey Dtha9180,
The key is that glycolysis and gluconeogenesis have some separate irreversible steps. So if one process is driven in a certain direction, the other one doesn't necessarily go the other way. If we added in a bunch of hexokinase, then yep- glycolysis would be driven forward by having more glucose.
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