Page 157

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Page 157

Post by MCAT_Retaker » Thu Jun 14, 2018 5:27 pm

Is ther a mistake on page 157- biochem book.
From my understanding is, fructose 2,6 bisphosphae is just a regualtory step between the 3rd adn 4th step of glycoslysis, right, and is allostericaly inactivated by glucagon, is that right?
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Re: Page 157

Post by NS_Tutor_Alex » Fri Jun 15, 2018 3:10 pm

Hi MCAT_Retaker,

This is a common source of confusion over Fructose 2,6-bisphosphate. This molecule regulates both PFK-1 and fructose 1,6-bisphosphatase. The effect is the upregulation of glycolysis and the downregulation of gluconeogenesis. Further, Glucagon will allosterically regulate the enzyme that makes/breaks down fructose 2,6-bisphophate and the result is an increase in its breakdown and decrease in its formation.

Hope that helps!
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