FL #1 C/P Question 26

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heatfan
Posts: 26
Joined: Sun Apr 30, 2017 12:34 pm

FL #1 C/P Question 26

Post by heatfan » Sun Jun 10, 2018 1:53 am

Hello,

I just wanted to know what in vivo IC50 means? I know in the passage it states that " in vivo IC50 values (the minimum plasma concentration needed to inhibit 50% of target enzyme activity in vivo". What does this mean in laymen's term? Additionally, why is .0012 uM the right value? Shouldn't it be 0.069 uM that we use for the calculation? Thanks.
NS_Tutor_Katelyn
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Re: FL #1 C/P Question 26

Post by NS_Tutor_Katelyn » Mon Jun 11, 2018 3:06 pm

heatfan wrote:Hello,

I just wanted to know what in vivo IC50 means? I know in the passage it states that " in vivo IC50 values (the minimum plasma concentration needed to inhibit 50% of target enzyme activity in vivo". What does this mean in laymen's term? Additionally, why is .0012 uM the right value? Shouldn't it be 0.069 uM that we use for the calculation? Thanks.
The IC50 refers to the amount of inhibitor necessary to achieve 50% inhibition. That means that, if the IC50 of an inhibitor is X, that it requires X amount of the inhibitor to inhibit 50% of the target compound. The smaller the IC50, the more powerful/potent/effective the inhibitor is.

0.012 is the correct IC50 because the question stem tells us that we are working at a pH of 7.4, and that is the value given in the table for that pH range (0.069 is the value for pH 9.6-12.5)
Katelyn Sawyer
Senior Tutor
katelyn@nextsteptestprep.com
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