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QBANK Biochem Proteins & Enzymes #11
Posted: Fri Jan 12, 2018 11:17 am
I find this question very nuanced and though i agree with the explanation, when i looked at the question stem again, its asking for a molecule and a transition state is not a molecule?? What you think? Thank you
Re: QBANK Biochem Proteins & Enzymes #11
Posted: Sun Jan 14, 2018 8:44 pm
Yes, this is a tricky question that draws on a less commonly known aspect of how enzymes work, although when you think about it, it's logical that they will have a very high affinity for the transition state. (The Wikipedia article on transition-state analogs
is interesting reading in this regard). To answer your specific question, though, the correct answer states that the researcher would develop a molecule that resembles
the transition state, which is not quite the same as stating that the transition state is
a molecule. In general, MCAT questions will tend to be worded in a way that sidesteps thorny theoretical/philosophical issues like the precise nature of a transition state.
Hope this help clarify things, and that your studying is going well!