Blding proteins?? Science Qbk # 26 Bio

PoincareConjecture
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Joined: Wed Mar 29, 2017 3:37 pm

Blding proteins?? Science Qbk # 26 Bio

Postby PoincareConjecture » Wed Sep 13, 2017 9:36 pm

5'-TTTTTCGTG-3'----So this is the sense strand and the mRNA should be exactly similar with Uracil in place of Thymine----How do you organize this mRNA for the proteins to be arranged into a N to C Fashion----is the 3' prime end the N terminus; Would the mRNA be "interestingly" read in a 5'to3" fashion in the Ribosome ignorer for the translation off the anticodon to come off in a "3'to5" convention which spells the N to C pattern----how do you determine the end terminus from an mRNA i guess is my ?
Thank you:) ;)
NS_Tutor_Andrew
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Re: Blding proteins?? Science Qbk # 26 Bio

Postby NS_Tutor_Andrew » Fri Sep 15, 2017 12:38 pm

Hi PoincareConjecture,

This is one of those cases where the conventions we use to write biomolecules actually make your life easy. mRNA is 'read' by the ribosome in the 5'-3' direction and proteins are also synthesized in the N-to-C direction, so you can take that sense sequence, convert it into a 5'-3' mRNA sequence, and just straightforwardly map it onto amino acids: 5' UUU (Phe) UUC (Phe) GUG (Val) 3'. Another way of thinking about this is that we have chosen to refer to proteins in the way that corresponds to how they're actually synthesized.

Hope this helps & best of luck!
Andrew D.
Content Manager, Next Step Test Prep.
PoincareConjecture
Posts: 93
Joined: Wed Mar 29, 2017 3:37 pm

Re: Blding proteins?? Science Qbk # 26 Bio

Postby PoincareConjecture » Sat Sep 16, 2017 3:44 pm

Agreed, thank you:)

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