Biology Qbank 1: Molecular Genetics #20

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Biology Qbank 1: Molecular Genetics #20

Post by jnmoonlight » Fri Aug 31, 2018 3:18 pm


This question talks about how there is a missense mutation from Ala to Val, and what are the possible effects of this mutation?
There were two options I was stuck between: no effect, or disrupted in folding due to the steric hindrance.

I chose the steric hindrance one in the end because valine's side chain is bigger than the R group on Ala. But it turned out to be that there would be no effect. I was wondering what I was missing so I can be more successful the next time a similar question comes up.

Thank you!
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Re: Biology Qbank 1: Molecular Genetics #20

Post by NS_Tutor_Phil » Tue Sep 04, 2018 5:18 pm

While there is a difference in size, it isn't much. If you mutated alanine into tryptophan --> that would likely cause an increase in steric interference.
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